Amanda Knox (Grace Van Patten), a 20-year-old college student traveling to Perugia, Italy, is arrested for murder along with her boyfriend Raffaele Sollcito (Giuseppe De Domenico) after the murder of her roommate, Meredith Kercher. The series follows Amanda’s arduous journey to prove her innocence, while the media and investigator Giuliano Mini (Francesco Acquaroli) try to prove her guilt.